Within SARS-CoV-2 and COVID-19 mRNA vaccines is a protein called ORF10 protein. Studies have concluded that ORF10 acts as a precursor of additional RNAs in roles concerning gene expression, controlling cellular antiviral pathways, or within viral replication (Taiaroa et al., 2020). ORF10 of SARS-CoV-2 is the last predicted coding sequence upstream of the poly-A tail and is the shortest predicted coding sequence, composed of 38 a.a. (Taiaroa et al., 2020). ORF10 is predicted to harbor a long helix and a pair of ϐ-strands. ORF10 is not found within the SARS-CoV-1 proteome (Taiaroa et al., 2020).
ORF10 is the only protein that is present exclusively/only in SARS-CoV-2 and not in SARS-CoV or any other human coronaviruses.
The WHO reported that the severity of COVID-19 is enhanced by the ORF10 protein.
“These findings of uniqueness of ORF10 and predicted intrinsic characteristics support possible involvement of ORF10 protein in giving COVID-19 its specific characteristics like spread and virulence.” World Heath Organization
Virulence is a pathogen’s or microorganism’s ability to cause damage to a host. In most contexts virulence refers to the degree of damage caused by a microbe to its host. The pathogenicity of an organism — its ability to cause disease — is determined by its virulence factors.
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